Copper-catalyzed aerobic oxidation of N-substituted hydroxylamines: efficient and practical access to nitroso compounds

…, A Bugarin, JR Engelking, J Read de Alaniz

Index: Frazier, Charles P.; Bugarin, Alejandro; Engelking, Jarred R.; Read De Alaniz, Javier Organic Letters, 2012 , vol. 14, # 14 p. 3620 - 3623

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Citation Number: 53

Abstract

A general and efficient aerobic oxidation of N-substituted hydroxylamines is described. The mild reaction conditions employed provide a catalytic and sustainable alternative to stoichiometric oxidation methods to gain access to a range of nitroso compounds, such as acylnitroso, nitrosoformate, nitrosoformamide, iminonitroso, arylnitroso, and P- nitrosophosphine oxide derivatives in excellent yield.