Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines

M Abid, AR Bhat, F Athar, A Azam

Index: Abid, Mohammad; Bhat, Abdul Roouf; Athar, Fareeda; Azam, Amir European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 417 - 425

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Citation Number: 71

Abstract

Thirty new pyrazoline derivatives were synthesized by cyclization of Mannich bases with thiosemicarbazides being substituted by different cyclic and aromatic amines. The structures of the compounds were elucidated by elemental analyses, UV, IR, 1H and 13C NMR and ESI-MS spectral data. The in vitro antiamoebic activity was evaluated against Entamoeba histolytica in comparison with metronidazole used as reference substance. Out of the 30 ...