Ethacrynic acid analogues lacking the α, β-unsaturated carbonyl unit—Potential anti-metastatic drugs

…, EK Vogel, JL Wharton, CM Tilley, CN Kaminski…

Index: Janser, Romy F.J.; Meka, Ranjith K.; Bryant, Zack E.; Adogla, Enoch A.; Vogel, Elizabeth K.; Wharton, Jaimie L.; Tilley, Cynthia M.; Kaminski, Catherine N.; Ferrey, Seth L.; Van slambrouck, Severine; Steelant, Wim F.A.; Janser, Ingo Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1848 - 1850

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Citation Number: 5

Abstract

A series of ethacrynic acid analogues, lacking the α, β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy ...