Tetrahedron Letters

A convenient methodology for the chemoselective reduction of a wide variety of functionalized alkenes

JH Babler, NA White

Index: Babler, James H.; White, Nicholas A. Tetrahedron Letters, 2010 , vol. 51, # 2 p. 439 - 441

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Citation Number: 4

Abstract

An efficient method to effect chemoselective reduction of alkenes (including trisubstituted olefins) possessing various sensitive and/or reducible groups such as acetals, allylic alcohols, benzyl ethers, epoxides, esters, halides, nitriles, and sulfones is reported. The reduction is facile at 0° C in aqueous N, N-dimethylacetamide containing sodium borohydride in the presence of 15mol% ruthenium (III) chloride. Regioselective reduction ...

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