Structure and tumor-promoting activity of analogs of anthralin (1, 8-dihydroxy-9-anthrone)

BL Van Duuren, A Segal, SS Tseng…

Index: Van Duuren,B.L. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, # 1 p. 26 - 31

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Citation Number: 52

Abstract

Seventeen analogues of the tumor-promoting agent anthralin were tested for the same biological property by repeated skin application on mouse skin using female ICR/Ha Swiss mice, after a single application of a subcarcinogenic dose of 7, 12-dimethylbenz [a] anthracene. Seven of the compounds tested are new compounds. They are 1, 8-diacetoxy-9- anthrone, 1, 8-dimyristoyloxy-9-anthrone, 1, 8-dihydroxy-lO-acety1-9-anthrone, 1, 8- ...