Development of a multigram synthesis of URB937, a peripherally restricted FAAH inhibitor

…, R Scarpelli, D Piomelli, T Bandiera

Index: Fiorelli, Claudio; Scarpelli, Rita; Piomelli, Daniele; Bandiera, Tiziano Organic Process Research and Development, 2013 , vol. 17, # 3 p. 359 - 367

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Citation Number: 5

Abstract

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield.