Investigation of the Pathways of Excess Electron Transfer in DNA with Flavin??Donor and Oxetane??Acceptor Modified DNA Hairpins
…, M von Meltzer, U Hennecke, T Carell
Index: Breeger, Sascha; Von Meltzer, Martin; Hennecke, Ulrich; Carell, Thomas Chemistry - A European Journal, 2006 , vol. 12, # 25 p. 6469 - 6477
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Citation Number: 34
Abstract
Abstract Oxetane is a potential intermediate that is enzymatically formed during the repair of (6–4) DNA lesions by special repair enzymes (6–4 DNA photolyases). These enzymes use a reduced and deprotonated flavin to cleave the oxetane by single electron donation. Herein we report synthesis of DNA hairpin model compounds containing a flavin as the hairpin head and two different oxetanes in the stem structure of the hairpin. The data show that ...
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