Rationally designed 'dipeptoid'analogues of cholecystokinin (CCK): C-terminal structure-activity relationships of α-methyl tryptophan derivatives

…, JM Eden, M Higginbottom, DR Hill, DC Horwell…

Index: Boden, P. R.; Eden, J. M.; Higginbottom, M.; Hill, D. R.; Horwell, D. C.; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 47 - 61

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Citation Number: 16

Abstract

Abstract This paper outlines the synthesis and C-terminal structure-activity relationships (SAR) of a series of α-methyl tryptophanylphenethylamide analogues of the neuropeptide cholecystokinin (CCK). CCK-B and CCK-A receptor binding affinities of these analogues are described and the contributions of the various side chains on the phenethylamide moiety to binding affinity are discussed. Several of the compounds prepared have CCK-B receptor ...