Tetrahedron letters

Copper-catalyzed amidations of bromo substituted furans and thiophenes

KR Crawford, A Padwa

Index: Crawford, Kenneth R; Padwa, Albert Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7365 - 7368

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Citation Number: 67

Abstract

The C N cross-coupling reaction between aromatic halides and amides has now been applied to 2-and 3-substituted bromofurans and bromothiophenes. Catalytic CuI in the presence of N, N′-dimethylethylenediamine as a ligand and K3PO4 or K2CO3 as the base furnished 2-and 3-substituted amidofurans and thiophenes ranging from 11 to 99% depending on the particular amide source used.