Synthetic Studies on Condensed-Azole Derivatives. IV. Synthesis and Anti-asthmatic Activities of co-Sulfamoylalkyloxyimidazo (1, 2-b) pyridazines.

M Kuwahara, Y KAWANO, H SHIMAZU…

Index: Kuwahara, Masaaki; Kawano, Yasuhiko; Shimazu, Hiroshi; Ashida, Yasuko; Miyake, Akio Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 122 - 131

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Citation Number: 17

Abstract

A series of novel (imidazo [1, 2-b] pyridazin-6-yl) oxyalkylsulfonamides was synthesized and evaluated for the ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. The compounds bearing a gem-dialkyl or a cycloalkylidene group at the 2 position of the sulfamoylpropyloxy group in the side chain were found to have potent activity. Among them, 3-(imidazo [1, 2-b] pyridazin-6-yl) oxy-2, 2-dimethylpropanesulfonamide (6) ...