Bromination of pyrazole-3 (5)-carboxylic acid
GA Akopyan
Index: Akopyan Russian Journal of General Chemistry, 2007 , vol. 77, # 9 p. 1652 - 1653
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Abstract
With a 1: 1: 1 molar ratio of I, NaOH, and Br2, the yield of compound II sharply falls (8.8%), and the major reaction product (90%) in this case is 4-bromopyrazole-3 (5)-carboxylic acid (III). 4-Bromopyrazole, mp 92oC, prepared by decarboxylation of compound II, is identical to the product prepared by direct bromination of pyrazole [2].
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