Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors
A El-Tayeb, A Qi, RA Nicholas, CE Müller
Index: El-Tayeb, Ali; Qi, Aidong; Nicholas, Robert A.; Mueller, Christa E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2878 - 2890
Full Text: HTML
Citation Number: 25
Abstract
ABSTRACT: A large series of derivatives and analogues of the uracil nucleotides UMP, UDP, and UTP with modifications in various positions of the uracil moiety and/or the phosphate groups were synthesized and evaluated at human P2Y2, P2Y4, and P2Y6 receptors. 2--(Ar) alkylthio substitution of UMP and UDP was best tolerated by the P2Y2 receptor. 2-Phenethylthio-UMP (13e) showed an EC50 value of 1.3 μM at P2Y2 and> 70- ...
Related Articles:
Convenient intermediates for the preparation of C-4 modified derivatives of pyrimidine nucleosides
[Miah, Anwar; Reese, Colin B.; Song, Quanlai Nucleosides and Nucleotides, 1997 , vol. 16, # 1-2 p. 53 - 65]
Synthesis and stability of S-cyanoethyl-protected 4-thiouridine and 2′-deoxy-4-thiouridine
[Tetrahedron Letters, , vol. 32, # 26 p. 3033 - 3034]
Synthesis and stability of S-cyanoethyl-protected 4-thiouridine and 2′-deoxy-4-thiouridine
[Tetrahedron Letters, , vol. 32, # 26 p. 3033 - 3034]
Synthesis and stability of S-cyanoethyl-protected 4-thiouridine and 2′-deoxy-4-thiouridine
[Tetrahedron Letters, , vol. 32, # 26 p. 3033 - 3034]
Synthesis and stability of S-cyanoethyl-protected 4-thiouridine and 2′-deoxy-4-thiouridine
[Tetrahedron Letters, , vol. 32, # 26 p. 3033 - 3034]