Journal of Fluorine Chemistry

A convenient synthesis of 2-(F-alkyl)-4-hydroxyquinolines [1]

H Wei-Yuan, L Yan-Song, L Long

Index: Huang, Wei-Yuan; Liu, Yan-Song; Lu, Long Journal of Fluorine Chemistry, 1994 , vol. 66, # 2 p. 209 - 214

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Abstract

Abstract A convenient new route to 2-(F-alkyl)-4-hydroxyquinolines has been developed. In the presence of triethylamine, treatment of ethyl 2, 2-dihydropolyfluoroalkanoates with aromatic amines in acetonitrile at 70 C led to a mixture of the corresponding enamines and imines, which was cyclized in polyphosphoric acid (PPA) at 170 C to give 2-(F-alkyl)-4- hydroxyquinolines in good yield.