Novel thiopyrano [3, 2-b] and cycloalkeno [1, 2-b] indole derivatives with high inhibitory properties in LTB 4 production

…, B Guardiola-Lemaître, D Manechez, P Renard

Index: Kuehm-Caubere, Catherine; Caubere, Paul; Jamart-Gregoire, Brigitte; Pfeiffer, Bruno; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Renard, Pierre European Journal of Medicinal Chemistry, 1999 , vol. 34, # 1 p. 51 - 61

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Citation Number: 15

Abstract

Series of thiopyrano [3, 2-b] and cycloalkeno [1, 2-b] indoles were synthesized and evaluated in order to determine thenecessary structural requirements for high leukotrienes biosynthesis inhibition. In vitro experiments showed that compounds 11b and 12b belonging to the second series were the most active and selective compounds on LTB4 production. Further in vivo investigations have shown additional very significant activity in the acute ...