Organic letters

Intramolecular formal oxa-[3+ 3] cycloaddition approach to the ABD system of phomactin A

KP Cole, RP Hsung

Index: Cole, Kevin P.; Hsung, Richard P. Organic Letters, 2003 , vol. 5, # 25 p. 4843 - 4846

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Citation Number: 36

Abstract

The ABD-ring of phomactin A was synthesized using an intramolecular formal oxa-[3+ 3] cycloaddion of an α, β-unsaturated iminium salt tethered to a 1, 3-diketone. This represents the first time that the 12-membered ring has been formed simultaneously with the 1- oxadecalin and should afford a facile route to the challenging structure of phomactin A.