Acylase I in the alcoholysis of α-substituted dicarboxylic acid esters and derivatives: enantio-and regioselectivity
A Liljeblad, J Lindborg, LT Kanerva
Index: Liljeblad, Arto; Lindborg, Jutta; Kanerva, Liisa T. Tetrahedron Asymmetry, 2000 , vol. 11, # 19 p. 3957 - 3966
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Citation Number: 16
Abstract
Enantio-and regioselective butanolyses of α-substituted dimethyl succinates (substituents: Me, MeO2CCH2, NH2, AcHN, PrCOHN, HO, MeO, PrO, AcO, PrCO2, HepCO2, Cl and Br) and glutarates (substituents: PrCONH and CbzNH) and that of methyl pyroglutamate with acylase I enzymes have been studied. Acylase I-catalyzed reactions were totally regioselective proceeding exclusively at the sterically more ...
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