Synthesis of novel selenium and tellurium-containing tetrazoles: a class of chalcogen compounds with antifungal activity

…, FN Victoria, PS Nascente, L Savegnago, G Perin…

Index: Libero, Francieli M.; Xavier, Mauricio C.D.; Victoria, Francine N.; Nascente, Patricia S.; Savegnago, Lucielli; Perin, Gelson; Alves, Diego Tetrahedron Letters, 2012 , vol. 53, # 24 p. 3091 - 3094

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Citation Number: 25

Abstract

We describe herein the synthesis and antifungal activity of new 5-arylchalcogenoalkyl-1H- tetrazoles 4. Arylchalcogenoalkyl-1H-tetrazoles 4 have been synthesized in high yields by reaction of arylchalcogenolate anions with chloronitriles 2, and subsequent [2+ 3] cycloaddition of resulting arylchalcogenoalkylnitriles 3 with sodium azide by zinc catalysis in aqueous solution. The obtained compound 4a was screened for antifungal activity and ...