Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3, 5-dialkylbenzofurans: the development of L- …

…, PC Belanger, J Scheigetz, C Dufresne…

Index: Lau, Cheuk K.; Belanger, Patrice C.; Scheigetz, John; Dufresne, Claude; Williams, Haydn W. R.; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1190 - 1197

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Citation Number: 22

Abstract

5 prep yield, mp, HPMN 5-lipoxygenase 5 R1 R2 R3 R4 method%“C analysesn ICw? nM ICw,'nM a Me HH OMe A 37 130 C17H1603 574 2065 b Me n-Pr H OMe A 87 83 C20H2203 31 130 c Me n-Pr C1 OMe A 75 104 C20H21C103 11 36 d Me C1 C1 OMe A 44 121 C17H14C1203 860 e Me t-Bu C1 OMe A 81 128 99 f Me n-Pr F OMe A 71 71 C20H2103F 7 129 i Me n-Pr C1 HA 77 69 C1gH1gC102 30 j Me n-Pr c1 c1 A 84 76 C19HlSC1202 26 k ...