Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

…, K Beebe, L Neckers, N Winssinger

Index: Garcia, Jose; Barluenga, Sofia; Beebe, Kristin; Neckers, Len; Winssinger, Nicolas Chemistry - A European Journal, 2010 , vol. 16, # 32 p. 9767 - 9771

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Citation Number: 13

Abstract

CubØ resin has been known since the 1850s [1] to contain active ingredients useful as pesticides and insecticides.[2] Fractionation of the active ingredients has led to the isolation of biosynthetically related flavonoids and rotenoids which have been reisolated from various botanical sources.[3] The most prominent and active ingredients are rotenone, deguelin and tephrosin (Figure 1). The toxic properties of rotenone were originally ascribed to its ...

Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis

[Chang, Dong-Jo; An, Hongchan; Kim, Kyoung-Suk; Kim, Hyun Ho; Jung, Jinkyung; Lee, Jung Min; Kim, Nam-Jung; Han, Young Taek; Yun, Hwayoung; Lee, Sujin; Lee, Geumwoo; Lee, Seungbeom; Lee, Ju Sung; Cha, Jong-Ho; Park, Ji-Hyeon; Park, Ji Won; Lee, Su-Chan; Kim, Sang Geon; Kim, Jeong Hun; Lee, Ho-Young; Kim, Kyu-Won; Suh, Young-Ger Journal of Medicinal Chemistry, 2012 , vol. 55, # 24 p. 10863 - 10884]

Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

Abstract

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