5-HT1 and 5-HT2 binding profiles of the serotonergic agents. alpha.-methylserotonin and 2-methylserotonin

AM Ismaiel, M Titeler, KJ Miller, TS Smith…

Index: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758

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Citation Number: 78

Abstract

Results The results of the radioligand binding studies are shown in Table I. In addition to 1- 3, the O-methyl ether of 3 (ie, 2-methyl-5-methoxytryphmine; 4) was also included in order to determine the importance of a free hydroxy group on receptor affinity. Other than for 5-HT (l), none of the tryptamine analogues display affinity for 5-HTIE sites (Le. K1< 10000 nM), and only 5-HT (1) binds at 5-HTl~ sites with appreciable affinity. a-Me-5-HT (2) binds at 5-HTlD ...