Tetrahedron Letters

An efficient one-pot organocatalytic synthesis of 9-(1H-indol-3-yl)-xanthen-4-(9H)-ones under mild aqueous micellar conditions

NC Ganguly, S Roy, P Mondal, R Saha

Index: Ganguly, Nemai C.; Roy, Sushmita; Mondal, Pallab; Saha, Rajat Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7067 - 7071

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Citation Number: 31

Abstract

An efficient and facile l-proline-catalyzed three-component coupling of 2- hydroxybenzaldehyde, 5, 5-dimethyl-1, 3-cyclohexanedione (dimedone), and indole has been accomplished under mild aqueous micellar conditions to deliver a small library of 9- (1H-indol-3-yl)-xanthen-4-(9H)-ones of potential biological relevance. Under optimized conditions [10mol% of l-proline, water (2mL), SDS (23mg, 0.08 mmol), rt], the reaction was ...