Tetrahedron Letters

Synthesis of the hindered N, N, N′-trisubstituted guanidine moiety of martinelline and martinellic acid

BB Snider, SM O'Hare

Index: Snider, Barry B.; O'Hare, Sean M. Tetrahedron Letters, 2001 , vol. 42, # 13 p. 2455 - 2458

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Citation Number: 61

Abstract

Martinellic acid (1a) and martinelline (1b) were isolated by Witherup, Varga and co-workers at Merck Research Laboratories from the roots of the tropical plant Martinella iquitosensis. 1 These alkaloids are the first naturally occurring nonpeptide bradykinin B 1 and B 2 receptor antagonists. The novel tricyclic pyrrolo[3,2-c]quinoline core has been the object of intense synthetic effort. 2 We have developed an eight-step synthesis of the model triamine 2, which ...