Convenient Synthesis of 1, 2, 3, 4-Tetrahydroisoquinoline-1-carboxylic Acid Derivatives via Isocyanide-Based, Three-Component Reactions

I Schuster, L Lázár, F Fülöp

Index: Schuster, Ildiko; Lazar, Laszlo; Fueloep, Ferenc Synthetic Communications, 2010 , vol. 40, # 16 p. 2488 - 2498

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Citation Number: 9

Abstract

The three-component reactions of 3, 4-dihydroisoquinolines, isocyanides, and benzyl chloroformate furnished 2-benzyloxycarbonyl-1, 2, 3, 4-tetrahydroisoquinoline-1- carboxamides in moderate to good yields. Hydrogenolysis or selective hydrolysis of the benzyloxycarbonyl group provided 1, 2, 3, 4-tetrahydroisoquinoline-1-carboxamides, further hydrolysis of which resulted in the corresponding 1, 2, 3, 4-tetrahydroisoquinoline-1- ...