Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2, 6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of …

…, V Kanagarajan, M Gopalakrishnan

Index: Thanusu; Kanagarajan; Gopalakrishnan Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 713 - 717

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Citation Number: 36

Abstract

In the present work, a new series of bis hybrid heterocycle comprising both piperidine and thiohydantoin nuclei together namely 3-(3-alkyl-2, 6-diarylpiperin-4-ylidene)-2- thioxoimidazolidin-4-ones 46–60 was synthesized by the treatment of the respective thiosemicarbazones 31–45 with chloroethyl acetate and anhydrous sodium acetate in refluxing ethanol for 4h and were characterized by melting point, elemental analysis, MS, ...