Tetrahedron

Palladium-catalyzed C–N bond formation: Synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines

CS Cho, DB Patel

Index: Cho, Chan Sik; Patel, Daksha B. Tetrahedron, 2006 , vol. 62, # 26 p. 6388 - 6391

Full Text: HTML

Citation Number: 47

Abstract

Cyclic and acyclic β-bromovinyl aldehydes are cyclized with an array of arylhydrazines in toluene at 125 °C in the presence of a palladium catalyst and a phosphorus chelating ligand together with NaO t Bu to give 1-aryl-1H-pyrazoles in moderate to good yields. ... Based on our recent

Related Articles:

A general method for copper-catalyzed arylation of arene C− H bonds

[Do, Hien-Quang; Khan, Rana M. Kashif; Daugulis, Olafs Journal of the American Chemical Society, 2008 , vol. 130, # 45 p. 15185 - 15192]

Toward safer processes for C− C biaryl bond construction: catalytic direct C− H arylation and tin-free radical coupling in the synthesis of pyrazolophenanthridines

[Hernandez, Susana; Moreno, Isabel; SanMartin, Raul; Gomez, German; Herrero, Maria Teresa; Dominguez, Esther Journal of Organic Chemistry, 2010 , vol. 75, # 2 p. 434 - 441]

Oxidative cyclization of arylhydrazones of chalcones and benzalacetones to pyrazoles by thianthrene cation radical

[Kovelesky, Albert C.; Shine, Henry J. Journal of Organic Chemistry, 1988 , vol. 53, # 9 p. 1973 - 1979]

Synthesis of pyrazoles via CuI-mediated electrophilic cyclizations of α, β-alkynic hydrazones

[Zora, Metin; Kivrak, Arif Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9379 - 9390]

Synthesis of pyrazoles via electrophilic cyclization

[Zora, Metin; Kivrak, Arif; Yazici, Ceyda Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6726 - 6742]

More Articles...