A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA …

…, A Zidovska, NF Bouxsein, A Ahmad…

Index: Ewert, Kai K.; Evans, Heather M.; Zidovska, Alexandra; Bouxsein, Nathan F.; Ahmad, Ayesha; Safinya, Cyrus R. Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 3998 - 4006

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Citation Number: 193

Abstract

Gene therapy holds great promise as a future approach to fighting disease and is explored in worldwide clinical trials. Cationic liposome (CL)-DNA complexes are a prevalent nonviral delivery vector, but their efficiency requires improvement and the understanding of their mechanism of action is incomplete. As part of our effort to investigate the structure- transfection efficiency relationships of self-assembled CL-DNA vectors, we have ...