Tetrahedron

First selective lithiation of pyridylpiperazines: straightforward access to potent pharmacophores

F Louërat, P Gros, Y Fort

Index: Louerat, Frederic; Gros, Philippe; Fort, Yves Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768

Full Text: HTML

Citation Number: 12

Abstract

The three isomers of pyridylpiperazines have been lithiated for the first time. The use of a superbase, an aminoalkoxide containing lithiating agent overcomes the chelating influence of the basic piperazine nitrogens, so that selective mono lithiation occurred alpha to ...