Cyclopeptide alkaloids. Synthesis of the ring system and its ion affinity

…, RA Houghten, H Rapoport

Index: Lagarias; Houghten; Rapoport Journal of the American Chemical Society, 1978 , vol. 100, # 26 p. 8202 - 8209

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Citation Number: 49

Abstract

Abstract: Several examples of the 14-membered, para-bridged ring system of the cyclopeptide alkaloids have been synthesized via an active ester cyclization. The yield of monomeric cyclopeptide varied from 1 to 33% and was affected by the amino acid substitution pattern and amide conformation of the linear peptide precursors. Both the synthetic models and a naturally occurring cyclopeptide alkaloid, ceanothine B, bind ...