Selective deprotection of TBDMS alkyl ethers in the presence of TIPS or TBDPS phenyl ethers by catalytic CuSO 4· 5H 2 O in methanol

…, CA González-González, S Assad-Hernández…

Index: Gonzalez-Calderon, Davir; Benitez-Puebla, Luis J.; Gonzalez-Gonzalez, Carlos A.; Assad-Hernandez, Salomon; Fuentes-Benitez, Aydee; Cuevas-Yanez, Erick; Corona-Becerril, David; Gonzalez-Romero, Carlos Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5130 - 5132

Full Text: HTML

Citation Number: 2

Abstract

Abstract TBDMS alkyl ethers are efficiently cleaved to the corresponding hydroxyl compounds upon heating (conventional or microwave) in methanol solution containing 20 mol% CuSO 4· 5H 2 O. Intramolecular chemoselective experiments showed that TBDMS alkyl ethers are selectively cleaved in the presence of TIPS or TBDPS aryl ethers. Competition experiments also showed that TBDMS alkyl ethers were selectively cleaved ...