Silver nitrate-promoted ring enlargement of 1-tribromomethyl-1, 2-dihydro-and 1-tribromomethyl-1, 2, 3, 4-tetrahydro-isoquinoline derivatives: application to the …
M Pauvert, S Collet, A Guingant
Index: Pauvert, Mickael; Collet, Sylvain; Guingant, Andre Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4203 - 4206
Full Text: HTML
Citation Number: 25
Abstract
The one step AgNO3-mediated ring enlargement of 1-tribromomethyl-1, 2-dihydro-and 1- tribromomethyl-1, 2, 3, 4-tetrahydro-isoquinoline derivatives into 1, 2-dihydro-and 1, 2, 3, 4- tetrahydro-benzo [d] azepin-2-ones, respectively, is reported. This reaction offers a convenient entry to potentially active substances such as the anti-anginal zatebradine.
Related Articles:
[Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2499 - 2512]
[Tetrahedron Letters, , vol. 44, # 22 p. 4203 - 4206]
[Tetrahedron Letters, , vol. 44, # 22 p. 4203 - 4206]
[Tetrahedron Letters, , vol. 44, # 22 p. 4203 - 4206]
[Tetrahedron Letters, , vol. 44, # 22 p. 4203 - 4206]