Benzotriazole-assisted preparations of 2-(substituted amino) pyridines and pyrid-2-ones

…, AE Sorochinsky, SA Henderson, J Chen

Index: Katritzky, Alan R.; Belyakov, Sergei A.; Sorochinsky, Alexander E.; Henderson, Scott A.; Chen, Jie Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6210 - 6214

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Citation Number: 67

Abstract

Base-promoted reactions of benzotriazolyl-containing acetic acid derivatives, 2- (benzotriazol-1-yl) acetonitrile (7a), 2-(benzotriazol-1-yl) acetamide (7b), and (±)-2- (benzotriazol-1-yl) propionamide (7c), with α, β-unsaturated ketones 8 give efficient and regioselective access to previously difficult to attain 3-unsubstituted pyridine derivatives: the 2-(substituted amino) pyridines 14a-k and the 4, 6-substituted pyrid-2-ones 15a-h. The ...