A very simple route to N-methylisatins: Friedel-Crafts acylation of p-substituted N, N-dimethylanilines with oxalyl chloride and DABCO
Y Cheng, HL Ye, YH Zhan, O Meth-Cohn
Index: Synthesis, , # 6 p. 904 - 908
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Citation Number: 10
Abstract
... [6] Isatins have also been extensively used as synthetic intermediates, for example, in the Pfitzinger synthesis of quinolines [7] and in the synthesis of quindolines. ... Thus, 3,4-dimethoxyaniline hydrochloride with oxalyl chloride gives 5,6-dimethoxyisatin in 5% yield. ...
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