Novel bronchodilatory quinazolines and quinoxalines: synthesis and biological evaluation

…, J Kuneš, J Vacek, M Ghavre, N Gathergood…

Index: Spulak, Marcel; Pourova, Jana; Voprsalova, Marie; Mikusek, Jiri; Kunes, Jiri; Vacek, Jan; Ghavre, Mukund; Gathergood, Nicholas; Pour, Milan European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 65 - 72

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Citation Number: 7

Abstract

Abstract A series of heterocyclic derivatives analogous to (−) vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4–O, C4–S or C4–N were used as the sites of attachment. The 4-[3-(1-piperidyl) propylsulfanyl] derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in ...