Complexes of. NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

CM Maragos, D Morley, DA Wink…

Index: Maragos, Chris M.; Morley, Deborah; Wink, David A.; Dunamas, Tambra M.; Saavedra, Joseph E.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3242 - 3247

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Citation Number: 703

Abstract

Nitric oxide ('NO) has recently been implicated in a variety of important bioregulatory processes, including normal physiological control of blood pressure, macrophage-induced cytostasis and cytotoxicity, and neurotransmission.'We have been interested in the possibility that agents of structure XN (0-) N= O, where X is a nucleophile residue, might serve as vehicles for the controlled delivery of'NO into a biological system and thus ...