New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis

…, R Polanowski, SM Krueger, R Ignasiak, M Rott…

Index: Kabir, M. Shahjahan; Engelbrecht, Kathleen; Polanowski, Rebecca; Krueger, Sarah M.; Ignasiak, Rachel; Rott, Marc; Schwan, William R.; Stemper, Mary E.; Reed, Kurt D.; Sherman, David; Cook, James M.; Monte, Aaron Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 21 p. 5745 - 5749

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Citation Number: 29

Abstract

An antimicrobial phenolic stilbene,(E)-3-hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others. These results prompted the design and synthesis of two ...