The Journal of Organic Chemistry

Synthesis of a Homolog of Aspergillic Acid

M Masaki, M Ohta

Index: Masaki,M.; Ohta,M. Journal of Organic Chemistry, 1964 , vol. 29, p. 3165 - 3168

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Citation Number: 9

Abstract

The 6-propyl homolog of aspergillic acid was synthesized. N-Leucyl-0-benzylhydroxylamine, prepared by reaction of phthalylleucyl chloride with 0-benzylhydroxylamine, followed by treatment with hydrazine hydrate, was treated with 1-chloro-2-pentanone oxime; the product was hydrolyzed to give N-[4-methyl-2-(2-oxopentyl-amino) valeryl]-0-benzylhydroxylamine, which was catalytically hydrogenated to give the corresponding hydroxamic acid. The ...