A new series of cyclic amino acids as inhibitors of S-adenosyl L-methionine synthetase

K Lavrador, D Guillerm, G Guillerm

Index: Lavrador, Karine; Guillerm, Danielle; Guillerm, Georges Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 13 p. 1629 - 1634

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Citation Number: 23

Abstract

Optically active 3-amino-3-(tetrahydrofuranyl) carboxylic acid, 3-amino-3-(tetrahydrothienyl) carboxylic acid and their corresponding six membered ring analogues have been synthesised and examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver AdoMet synthetase (α-isoform) fractionated from E. coli transformed ...