Thieme Chemistry Journal Awardees-Where are They Now? A General One-Step Synthesis of Alkynes from Enolisable Carbonyl Compounds

IM Lyapkalo, MAK Vogel, EV Boltukhina, J Vavřík

Index: Lyapkalo, Ilya M.; Vogel, Michael A. K.; Boltukhina, Ekaterina V.; Vavrik, Jiri Synlett, 2009 , # 4 p. 558 - 561

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Citation Number: 6

Abstract

Abstract Terminal and internal acetylenes were obtained in good to excellent isolated yields from carbonyl compounds by converting the carbonyl functionality into the enol nonaflate intermediate followed by elimination to give the CC triple bond. The one-pot transformations were uniformly induced by phosphazene bases combined with mildly electrophilic nonafluorobutane-1-sulfonyl fluoride. The method is the most general among those ...