Multivalent antibiotics via metal complexes: potent divalent vancomycins against vancomycin-resistant enterococci

…, PL Ho, KH Chow, T Cheung, H Gu, Z Cai…

Index: Xing, Bengang; Yu, Chun-Wing; Ho, Pak-Leung; Chow, Kin-Hung; Cheung, Terence; Gu, Hongwei; Cai, Zongwei; Xu, Bing Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4904 - 4909

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Citation Number: 33

Abstract

Dimers of vancomycin (Van), linked by a rigid metal complex,[Pt (en)(H2O) 2] 2+, exhibit potent activities (MIC~ 0.8 μg/mL,~ 720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.