Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: Synthesis, antiviral activity and decomposition study

…, M Fournier, F Zoulim, J Balzarini, B Canard…

Index: Roux, Loic; Priet, Stephane; Payrot, Nadine; Weck, Clement; Fournier, Maelenn; Zoulim, Fabien; Balzarini, Jan; Canard, Bruno; Alvarez, Karine European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 869 - 881

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Citation Number: 13

Abstract

9-[2-(Thiophosphonomethoxy) ethyl] adenine [S-PMEA, 8] and (R)-9-[2-( Thiophosphonomethoxy) propyl] adenine [S-PMPA, 9] are acyclic nucleoside thiophosphonates we described recently that display the same antiviral spectrum (DNA viruses) as approved and potent phosphonates PMEA and (R)-PMPA. Here, we describe the synthesis, antiviral activities in infected cell cultures and decomposition study of bis ( ...