Niobium pentachloride catalysed ring opening of epoxides
MG Constantino, V Lacerda, V Aragão
Index: Gomes Constantino, Mauricio; Lacerda Jr., Valdemar; Aragao, Valquiria Molecules, 2001 , vol. 6, # 9 p. 770 - 776
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Citation Number: 43
Abstract
Abstract: Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl 5 for this purpose using three different substrates. Chlorohydrins, 1, 2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested.
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