Tetrahedron

Synthesis of 4-(3-hydroxyalkyl) pyrimidines by ring transformation reactions of 2-alkylidenetetrahydrofurans with amidines

E Bellur, P Langer

Index: Bellur, Esen; Langer, Peter Tetrahedron, 2006 , vol. 62, # 23 p. 5426 - 5434

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Citation Number: 26

Abstract

Functionalized pyrimidines 1, 1a, 1b, 1c, 1d, 1e, 1f and 1g play an important role as analgesic, 1a antihypertensive, 1b antipyretic, 1c and anti-inflammatory drugs, 1d as pesticides, 1e herbicides, 1f and plant growth regulators. 1g For example, the naturally occurring l-lathyrine shows a wide range of biological activity, such as pollen growth inhibition, antitumor, and hypoglycaemic activity (Fig. 1). 2, 2a and 2b Although pyrimidine ...