InCl3??Driven Regioselective Synthesis of Functionalized/Annulated Quinolines: Scope and Limitations

T Chanda, RK Verma, MS Singh

Index: Chanda, Tanmoy; Verma, Rajiv Kumar; Singh, Maya Shankar Chemistry - An Asian Journal, 2012 , vol. 7, # 4 p. 778 - 787

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Citation Number: 35

Abstract

Abstract The efficient, regioselective synthesis of functionalized/annulated quinolines was achieved by the coupling of 2-aminoaryl ketones with alkynes/active methylenes/α- oxoketene dithioacetals promoted by InCl 3 in refluxing acetonitrile as well as under solvent- free conditions in excellent yields. This transformation presumably proceeded through the hydroamination–hydroarylation of alkynes, and the Friedländer annulation of active ...