Nonsteroidal antiinflammatory agents. 1. 2, 4-Diphenylthiazole-5-acetic acid and related compounds

K Brown, DP Cater, JF Cavalla, D Green…

Index: Newberry,R.A. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1177 - 1181

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Citation Number: 33

Abstract

A variety of novel 2, 4-diarylthiazole-5-acetic acids and related compounds was prepared by the Hantzsch thiazole synthesis and evaluated as antiinflammatory agents on the carrageenin-induced edema assay in the rat. Two compounds, namely 4-(4-chlorophenyl)-2- phenylthiazole-5-acetic acid (24) and 4-(4-chlorophenyl)-2-(3-methylphenyl)-thiazole-5- acetic acid (31), were found to possess activity comparable with indomethacin. Derivatives ...