Synthesis of 2trans??alkene??mono??and??poly??ynoic acids with a triple bond in the 5??position and their hydrogenation. A new synthesis of arachidonic acid
L Heslinga, HJJ Pabon…
Index: Heslinga,L. et al. Recueil des Travaux Chimiques des Pays-Bas, 1973 , vol. 92, p. 287 - 303
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Citation Number: 20
Abstract
Abstract 27Trans-alkenoic, 2trans-alkenemonoynoic and 2trans-alkenepolyynoic acids with the first triple bond in the 5-position could be obtained in high yield by coupling 1-alkyl-and 1- mono-or-poly-ynylmagnesium bromides with 4-bromocrotonic acid in tetrahydrofuran at low temperature.
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