The α-arylation of derivatives of malonic acid with aryllead triacetates. New syntheses of ibuprofen and phenobarbital.
JT Pinhey, BA Rowe
Index: Pinhey, John T.; Rowe, Bruce A. Tetrahedron Letters, 1980 , vol. 21, p. 965 - 968
Full Text: HTML
Citation Number: 37
Abstract
Abstract Derivatives of Meldrum's acid and the sodium salts of substituted malonic esters undergo rapid arylation in high yield when treated with aryllead triacetates. These reactions have been applied to the synthesis of ibuprofen, an analgesic, and in a closely related reaction 5-ethylbarbituric acid has been reacted with phenyllead triacetate to give phenobarbital.
Related Articles:
[Kopinski, Richard P.; Pinhey, John T.; Rowe, Bruce A. Australian Journal of Chemistry, 1984 , vol. 37, # 6 p. 1245 - 1254]
[Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G. Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702]
[Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G. Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702]
[Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G. Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702]
[Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G. Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702]