3, 5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors

R Jiang, D Duckett, W Chen, J Habel, YY Ling…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 22 p. 6378 - 6382

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Citation Number: 28

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Scripps Florida, 5353 ... To improve the overall physicochemical properties of the molecules as well as to facilitate chemical SAR, the b-ring of 1 was eliminated, resulting in compounds of type 3 (Fig. ...

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