Synthesis and Modification of a Novel 1. BETA.-Methyl Carbapenem Antibiotic, S-4661.

…, T Irie, T Iwaki, M Kii, Y Sendo, K Motokawa…

Index: Iso; Irie; Iwaki; Kii; Sendo; Motokawa; Nishitani Journal of Antibiotics, 1996 , vol. 49, # 5 p. 478 - 484

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Citation Number: 51

Abstract

We describe an efficient method for introducing a sulfamoylamino group into the C-2'position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.