Asymmetric synthesis of a cytotoxic amide of Telesto riisei

S Sankaranarayanan, S Chattopadhyay

Index: Sankaranarayanan, Sivaraman; Chattopadhyay, Subrata Tetrahedron Asymmetry, 1998 , vol. 9, # 8 p. 1345 - 1350

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Citation Number: 5

Abstract

An efficient synthesis of both the enantiomers of N-(2-phenylethyl)-8- hydroxypentadecacarboxamide using the cytotoxic principles of Telesto riisei has been formulated using cyclohexylideneglyceraldehyde 1 as the chiral template. A non- stereoselective Grignard addition to the aldehyde 1 gave the C-3 epimers of the required chiron, 3-alkylglycerol which were converted to the title compound via a standard ...