Synthetic Communications

Facile Conversion of Aldehydes and Ketones to gem-Dichlorides Using Chlorodiphenylphosphine/N-Chlorosuccinimide as a New and Neutral System

G Aghapour, A Afzali

Index: Aghapour, Ghasem; Afzali, Asieh Synthetic Communications, 2008 , vol. 38, # 22 p. 4023 - 4035

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Citation Number: 11

Abstract

The conversion of aldehydes and ketones to the corresponding gem-dichlorides is a very important transformation in organic synthesis because these compounds can serve as precursors to transition-metal alkylidenes for carbonyl olefination [ 1 1. (a) Piotrowski , AM ; Malpass , DB ; Boleslawski , MP ; Eisch , JJ Alkylenation with geminal dialuminoalkane reagents: The synthesis of olefins from ketones . J. Org. Chem. 1988 , 53 , 2829 – 2835 ; (b) Takai , K. ; Shinomiya ...